Michael L. Hayes, PhD
271 La Kretz Hall ▪ CSULA ▪ Los Angeles, CA 90034
(323) 343-2144 ▪ mhayes3 (at) calstatela.edu
Summary of Qualifications
I teach fundamentals of biochemistry and plant molecular biology to undergraduate and graduate students. I work with students to translate scientific concepts into a defined research program. Currently my laboratory is researching the structure and function of a C-to-U RNA editing complex including an enzyme called the DYW-deaminase.
Ph.D. Biochemistry, Molecular & Cellular Biology Mentor: Prof. Maureen Hanson, Ph.D.
Cornell University, Ithaca, NY 2002 – 2008
B.S. Agricultural Biotechnology & Biology Mentor: Prof. Glenn Collins, Ph.D.
University of Kentucky, Lexington, KY 1998 – 2002
California State university, Los Angeles, CA 2015– Present
Assistant Project Scientist
University of California Irvine, Irvine, CA 2013–2015
University of California Irvine, Irvine, CA 2009– 2013
University of California Santa Barbara, Santa Barbara, CA 2008– 2009
Cornell University, Ithaca, NY 2002 – 2008
Teaching Experience and Community Involvement
Faculty Co-Sponsor of the Biochemistry Club
California State university los angeles, Los Angeles 2018 – Present
Assistant Professor of Biochemistry
California State university los angeles, Los Angeles 2015 – Present
Solano Canyon Community Garden and Urban Farm, Los Angeles, CA 2010 – 2015
University of California Irvine, Irvine, CA 2009 – 2015
Graduate / Undergraduate Mentor
Cornell University, Ithaca, NY 2004 – 2007
Cornell University, Ithaca, NY 2002 – 2003
Editor / Webmaster / Board Member
Liberty Hyde Bailey Garden Club, Ithaca, NY 2005 – 2007
Poster Award for Outstanding Poster Presentation
Gordon Research Conference: RNA Editing, Ventura, CA 2007
Predoctoral NIH Training Fellow
Cornell University, Ithaca, NY 2005 – 2006
16th Penn State Plant Symposium, Penn State University, University Park, PA 2006
Award for Outstanding Presentation
CSPP/SCPV 2004 Annual Meeting, Guelph, ON, Canada 2004
University of Kentucky, Lexington, KY 2000 – 2002
Conferences and Meetings
Gordon Research Conference: Chloroplast Biotechnology 2019
Gordon Research Conference: Mitochondria and Chloroplasts, Lucca, Italy 2018
23rd Annual RNA Society Meeting, Berkeley, CA 2018
Western Divisional Meeting of the American Society of plant biologists, Fullerton, CA 2018
Gordon Research Conference: Chloroplast Biotechnology, Ventura, CA 2017
Gordon Research Conference: Chloroplast Biotechnology, Ventura, CA 2015
3rd International symposium on chloroplast genomics and genetic engineering, Rutgers, NJ 2013
Gordon Research Conference: Mitochondria & Chloroplasts, Smithfield, RI 2012
Hayes ML and Santibanez P. A pentatricopeptide repeat protein with a DYW-deaminase domain is sufficient for catalyzing C-to-U RNA editing in vitro. Journal of Biological Chemistry 2020. In press.
Sandoval R., Boyd RD, Kiszter AN, Mirzakhanyan Y, Santibańez P, Gershon PD, and Hayes ML. Stable native RIP9 complexes associate with C-to-U RNA editing activity, PPRs, RIPs, OZ1, ORRM1, and ISE2. Plant J. 2019 99::1116-1126.
Diaz MF, Bentolila S, Hayes ML, Hanson MR, Mulligan RM. A protein with an unusually short PPR domain, MEF8, affects editing at over 60 Arabidopsis mitochondrial C targets of RNA editing. Plant J. 2017. doi: 10.1111/tpj.13709. PubMed PMID: 29035004.
Hayes ML, Dang KN, Diaz MF, Mulligan RM. A conserved glutamate residue in the C-terminal deaminase domain of pentatricopeptide repeat proteins is required for RNA editing activity. Journal of Biological Chemistry. 2015 290:10136-42.
Hayes ML, Giang K, Berhane B, Mulligan RM. Identification of two pentatricopeptide repeat genes required for RNA editing and zinc binding by C-terminal cytidine deaminase-like domains. Journal of Biological Chemistry. 2013 288: 36519-29.
Hayes ML, Giang K, Mulligan RM. Molecular evolution of pentatricopeptide repeat genes reveals truncation in species lacking an editing target and structural domains under distinct selective pressures. BMC Evolutionary Biology. 2012 12: 66.
Hayes ML, Mulligan RM. Pentatricopeptide repeat proteins constrain genome evolution in chloroplasts. Molecular Biology and Evolution. 2011 28(7): 2029-39.
Hayes ML, Hanson MR. High conservation of a 5’ element required for RNA editing of a C target in chloroplast psbE transcripts. Journal of Molecular Evolution. 2008 67: 233-45.
Heller WP, Hayes ML, Hanson MR. Cross-competition in editing of chloroplast RNA transcripts in vitro implicates sharing of trans-factors between different C targets. Journal of Biological Chemistry. 2008 283: 7314-7319.
Hayes ML and Hanson MR. Assay of editing of exogenous RNAs in chloroplast extracts of Arabidopsis, maize, pea, and tobacco. Methods of Enzymology. 2007 424: 459-482.
Hayes ML and Hanson MR. Identification of a sequence motif critical for editing of a tobacco chloroplast transcript. RNA. 2007 13: 281-288.
Hayes ML, Reed ML, Hegeman CE, and Hanson MR. Sequence elements critical for efficient RNA editing of a tobacco chloroplast transcript in vivo and in vitro. Nucleic Acids Research. 2006 34: 3742-3754.
Hegeman CE, Hayes ML, and Hanson MR. Substrate and cofactor requirements for RNA editing of chloroplast transcripts in Arabidopsis in vitro. Plant J. 2005 42: 124-132.