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Welcome to Wang Research Lab

  • Fall 2022 lab group photo at La Kretz
    Fall 2022 lab group photo at La Kretz
  • Our Fall 2022 Group Picture! Recreating the Chemistry Faculty Picture.
    Our Fall 2022 Group Picture! Recreating the Chemistry Faculty Picture.
  • A Selfie of All Lab Members!
    A Selfie of All Lab Members!
  • Adaly Garcia, Wang lab group
  • Wang lab group
  • Aimee Anguiano
  • students at work

NEWS

Sheehan_MORE

Sheehan Belleca at the MORE Graduating Class Poster Presentation

02/10/23 - Congratulations to Sheehan Belleca for presenting her project on alpha-Synuclein interaction on SH-SY5Y cells at the MORE Graduating Class Poster Presentation held at La Kretz Lobby.

newpaper_Langmuir

New paper published on Langmuir

12/14/2022 - The Wang lab, in collabroation with Tian lab at CSU Long Beach, recently published a paper entitled "pH-Responsive Metal–Organic Framework Thin Film for Drug Delivery", where we explored the use of MIL-88B(Fe) as a pH-stimuli thin film for drug delivery. Read more about it here.

newpaper_SICM

New published paper on ACS Chem. Neuroscience

12/01/2022 - The Wang lab, in collaboration with Porter lab, recently published a paper entitled "Observation of α-Synuclein Preformed Fibrils Interacting with SH-SY5Y Neuroblastoma Cell Membranes Using Scanning Ion Conductance Microscopy," which used SICM to monitor cytoplasmic membrane changes of SH-SY5Y neuroblastoma cells after incubation with varying concentrations of α-Syn PFFs. Read more about it here.

OUR RESEARCH

cells

Single cell analysis in Parkinson's disease

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the death of dopamine-producing neurons in the substantia nigra region of the midbrain. In our lab, we study the molecular mechanisms of alpha-synuclein and its aggregates associated with PD using imaging techniques such as scanning ion conductance microscopy and surface plasmon resonance microscopy.  

Single nanoparticle electrochemistry

Single nanoparticle electrochemistry

Single-Entity Electrochemistry is essential for understanding the fundamental dynamics of real-world systems that are often heterogeneous. We use plasmonic electrochemical microscopy, an optical imaging based electrochemical technique, to study SEE at individual metallic and non-metallic nanoparticles. 

Environmental Applications

Environmental Applications

We are interested in applying analytical techniques in studying general environmental concerns such as particulate matter (PM) and microplastic pollution. Ongoing projects include (1) monitoring the effect of PM exposure on membranes of human lung cells and neuroblastoma cells using scanning ion conductance microscopy; (2) sampling and characterizing microplastics from LA coastal area; (3) monitoring the degradation of polyethylene terephthalate powder and its effect on adsorbing toxic organic compounds.

nanopipette

Electrochemistry at nanoscopic interfaces

We are interested in fundamental studies and sensing applications of electrochemistry at nanoscopic interfaces. One project focuses on carbon nanoelectrodes and their applications in intracellular detection of active species and chemical sensing. The second one focuses on understanding interfacial-ion-transfer (IIT) kinetics at nanopipette-supported interface between two immiscible electrolyte solutions (ITIES).