Visit Health Watch for COVID-19 updates. Find Employee Return to Campus and Student Return to Campus information.
Emergency Notification
NEWS
Sheehan Belleca at the MORE Graduating Class Poster Presentation
02/10/23 - Congratulations to Sheehan Belleca for presenting her project on alpha-Synuclein interaction on SH-SY5Y cells at the MORE Graduating Class Poster Presentation held at La Kretz Lobby.
New paper published on Langmuir
12/14/2022 - The Wang lab, in collabroation with Tian lab at CSU Long Beach, recently published a paper entitled "pH-Responsive Metal–Organic Framework Thin Film for Drug Delivery", where we explored the use of MIL-88B(Fe) as a pH-stimuli thin film for drug delivery. Read more about it here.
New published paper on ACS Chem. Neuroscience
12/01/2022 - The Wang lab, in collaboration with Porter lab, recently published a paper entitled "Observation of α-Synuclein Preformed Fibrils Interacting with SH-SY5Y Neuroblastoma Cell Membranes Using Scanning Ion Conductance Microscopy," which used SICM to monitor cytoplasmic membrane changes of SH-SY5Y neuroblastoma cells after incubation with varying concentrations of α-Syn PFFs. Read more about it here.
OUR RESEARCH
Single cell analysis in Parkinson's disease
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the death of dopamine-producing neurons in the substantia nigra region of the midbrain. In our lab, we study the molecular mechanisms of alpha-synuclein and its aggregates associated with PD using imaging techniques such as scanning ion conductance microscopy and surface plasmon resonance microscopy.
Single nanoparticle electrochemistry
Single-Entity Electrochemistry is essential for understanding the fundamental dynamics of real-world systems that are often heterogeneous. We use plasmonic electrochemical microscopy, an optical imaging based electrochemical technique, to study SEE at individual metallic and non-metallic nanoparticles.
Environmental Applications
We are interested in applying analytical techniques in studying general environmental concerns such as particulate matter (PM) and microplastic pollution. Ongoing projects include (1) monitoring the effect of PM exposure on membranes of human lung cells and neuroblastoma cells using scanning ion conductance microscopy; (2) sampling and characterizing microplastics from LA coastal area; (3) monitoring the degradation of polyethylene terephthalate powder and its effect on adsorbing toxic organic compounds.
Electrochemistry at nanoscopic interfaces
We are interested in fundamental studies and sensing applications of electrochemistry at nanoscopic interfaces. One project focuses on carbon nanoelectrodes and their applications in intracellular detection of active species and chemical sensing. The second one focuses on understanding interfacial-ion-transfer (IIT) kinetics at nanopipette-supported interface between two immiscible electrolyte solutions (ITIES).
