Peer-reviewed Papers

Harris, G., B. E. Holbein, H. Zhou, H. H. Xu and W. Chen. 2019. Potential mechanisms of mucin-enhanced Acinetobacter baumannii virulence in the mouse model of intraperitoneal infection. Infect Immun. Aug 12, 2019. pii: IAI.00591-19. doi: 10.1128/IAI.00591-19. [Epub ahead of print]

Harris, G., R. KuoLee, H. H. Xu and W. Chen. 2019. Acute intraperitoneal infection with a hypervirulent Acinetobacter baumannii isolate in mice. Sci Rep. Apr 25;9(1):6538. doi: 10.1038/s41598-019-43000-4. 

Luna, B. L., J. A. Garcia, M. Huang, P. J. Ewing, S. C. Valentine, Y. M. Chu, Q. Z. Ye and  H. H. Xu. 2018. Identification and characterization of novel isothiazolones with potent bactericidal activity against multi-drug resistant Acinetobacter baumannii clinical isolates. Int J Antimicrob Agents. 26-DEC-2018 DOI information: 10.1016/j.ijantimicag.2018.12.007 

Harris, G., R. KuoLee, H. H. Xu and W. Chen. 2017. Mouse Models of Acinetobacter baumannii infection. Curr Protoc Microbiol. Aug 11; 46:6G.3.1-6G.3.23. doi: 10.1002/cpmc.36.

Xu, Z., Y. Wang, K.F. Chater, H.Y. Ou, H. H. Xu, Z. Deng and M. Tao. 2017. Large-scale transposition mutagenesis of Streptomyces coelicolor identifies hundreds of genes influencing antibiotic biosynthesis. Appl Environ Microbiol. Jan 6. pii: AEM.02889-16. doi: 10.1128/AEM.02889-16. [Epub ahead of print]

Cheung Lam, A. H., N. Sandoval, R. Ritambhara, J. Gilkes, T. Q. Do, W. Ernst, S. M. Chiang, S. Kosina, H. H. Xu, G. Fujii and E. Porter. 2016. Assessment of free fatty acids and cholesteryl esters delivered in liposomes as novel class of antibiotics. BMC Research Notes. in press.

Ward, M.S., I. Silva, W. Martinez, J. Jefferson, S. Rahman, J, M, Garcia, D. Kanichar, L. Roppiyakuda, E. Kosmowska, M. A. Faust, K. P. Tran, F. Chow, E. Buglo, F. Zhou, M. P. Groziak and H. H. Xu. 2016. Identification of cellular targets of a series of boron heterocycles using TIPA II-A sensitive target identification platform. Bioorg Med Chem. pii: S0968-0896(16)30402-3. doi: 10.1016/j.bmc.2016.05.058. [Epub ahead of print].

Qiu, H., Z. Li, R. KuoLee, G. Harris, X. Gao, H. Yan, H. H. Xu and W. Chen. 2016. Host resistance to intranasal Acinetobacter baumannii reinfection in mice. Pathog Dis. 74(5). pii: ftw048. doi: 10.1093/femspd/ftw048. Epub 2016 May 17.

Warner, W.A., S. N. Kuang, R. Hernandez, M. C. Chong, P. J. Ewing, J. Fleischer, J. Meng, S. Chu, D. Terashita, L. English, W. Chen and H. H. Xu. 2016. Molecular characterization and antimicrobial susceptibility of Acinetobacter baumannii isolates obtained from two hospital outbreaks in Los Angeles County, California, USA. BMC Infect Dis. 16(1):194. doi: 10.1186/s12879-016-1526-y.

Jordan, C. A., B. A. Sandoval, M. V. Serobyan, D. H. Gilling, M. P. Groziak, H. H. Xu and J. L. Vey. 2015. Crystallographic insights into the structure-activity relationships of diazaborine enoyl-ACP reductase inhibitors. Acta Crystallogr F Struct Biol Commun. 71(Pt 12):1521-30.

Li, J., Y. Yao, H. H. Xu, L. Hao, Z. Deng, K. Rajakumar and H.Y. Ou. 2015. SecReT6: a web-based resource for type VI secretion systems found in bacteria. Environ Microbiol. Jan 30. doi: 10.1111/1462-2920.12794.

Ou, H.Y., S.N. Kuang, X. He, B.M. Molgora, P.J. Ewing, Z. Deng, M. Osby, W. Chen and H. H. Xu. 2015. Complete genome sequence of hypervirulent and outbreak-associated Acinetobacter baumannii strain LAC-4: epidemiology, resistance genetic determinants and potential virulence factors. Sci Rep. 5:8643.

Kanichar, D., L. Roppiyakuda, E. Kosmowska, M. A. Faust, K. P. Tran, F. Chow, E. Buglo, M. P. Groziak, E. A. Sarina, M. M. Olmstead, I. Silva and H. H. Xu. 2014. Synthesis, characterization, and antibacterial activity of structurally complex 2-acylated 2,3,1-benzodiazaborines and related compounds. Chem Biodivers. 11(9):1381-97.

Kuolee, R., G. Harris, H. Yan, H. H. Xu, W. J. Conlan, G. B. Patel and W. Chen. 2014. Intranasal immunization protects against Acinetobacter baumannii-associated pneumonia in mice. Vaccine. 33(1): 260-7.

Vinogradov, E., L. Maclean, H. H. Xu and W. Chen. 2014. The structure of the polysaccharide isolated from Acinetobacter baumannii strain LAC-4. Carbohydr Res. 390:42-5

Silva, I., L. J. Real, M.S. Ward and H. H. Xu. 2014. A disk-diffusion-based target identification platform for antibacterials (TIPA): an inducible assay for profiling MOAs of antibacterial compounds. Appl Microbiol Biotechnol. 98(12):5551-66.

de Léséleuc, L., G. Harris, R. Kuolee, H. H. Xu and W. Chen. 2014. Serum resistance, gallium nitrate tolerance and extrapulmonary dissemination are linked to heme consumption in a bacteremic strain of Acinetobacter baumannii. Int J Med Microbiol. 304 (3-4):360-9.

Feng, J., J. Wu, N. Dai, S. Lin, H. H. Xu, Z. X. Deng and X. Y. He. 2013. Discovery and characterization of BlsE, a radical S-adenosyl-L-methionine decarboxylase involved in the blasticidin S biosynthetic pathway. PLoS One. 8(7):e68545.

Harris, G., R. Kuo Lee, C. K. Lam, G. Kanazi, G. B. Patel, H. H. Xu, and W. Chen. 2013. A mouse model of Acinetobacter baumannii-associated pneumonia using a clinically isolated hypervirulent strain. Antimicrob Agents and Chemother. 57 (8):3601-3613.

Zhang, L., G. Yagnik, Y. Peng, J. Wang, H. H. Xu, Y. Hao, Y.N. Liu, and F. Zhou. 2013. Kinetic studies of inhibition of the amyloid beta (1-42) aggregation using a ferrocene-tagged β-sheet breaker peptide. Anal Biochem. 434(2):292-9.

Cheng, C., T.L. Gao, G. Zhao, Z.X. Deng, S.C. Hu, H. H. Xu and X. Y. He. 2013. Evidence from 18O feeding studies for hydroxyl group donor in the reaction catalyzed by cytidylate hydroxymethylase MilA. Chin Sci Bull. 58(8):.864-868.

Meng, J., G. Kanzaki, D. Meas, C. K. Lam, H. Crummer, J. Tain and H. H. Xu. 2012. A genome-wide inducible phenotypic screen identifies antisense RNA constructs silencing Escherichia coli essential genes. FEMS Microbiol Lett. 329(1):45-53.

Yuan, H., S. C. Chai, C. K. Lam, H. H. Xu and Q. Z. Ye. 2011. Two methionine aminopeptidases from Acinetobacter baumannii are functional enzymes. Bioorg Med Chem Lett. 21(11):3395-8.

Golanbar, G. D., C. K. Lam, Y. M. Chu, C. Cueva, S. W. Tan, I. Silva and H. H. Xu. 2011. Phenotypic and molecular characterization of Acinetobacter clinical isolates obtained from inmates of California correctional facilities. Journal of Clinical Microbiology. 49(6):2121-31.

Xu, H. H., J. D. Trawick, R. J. Haselbeck, R. A. Forsyth, R. T. Yamamoto, R. Archer, J. Patterson, M. Allen, J. M. Froelich, I. Taylor, D. Nakaji, R. Maile, K. G C, M. Pilcher, V. Brown-Driver, M. McCarthy, A. Files, D. Robbins, P. King, S. Sillaots, C. Malone, C. S. Zamudio, T. Roemer, L. Wang, P. J. Youngman, D. Wall. 2010. Staphylococcus aureus TargetArray: Comprehensive differential essential gene expression as a mechanistic tool to profile antibacterials. Antimicrob Agents Chemother.2010. 54:3659-3670.

Peng, Y., C. Wang, H. H. Xu, Y. N. Liu and F. Zhou. 2010. Binding of -synuclein with Fe3+ and with Fe2+ and biological implications of the resultant complexes. Journal of Inorganic Biochemistry. Journal of Inorganic Biochemistry. 104: 365-370.

Xu, H. H. 2010. Assay development for antimicrobial drug discovery. in T. Chen (ed.) A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery. Taylor and Francis; Boca Raton.

Piyasena, M. E., L. J. Real, R. A. Diamond, H. H. Xu and F. A. Gomez. 2008. Magnetic microsphere-based methods to study the interaction of teicoplanin with peptides and bacteria. Analytical and Bioanalytical Chemistry. 392: 877-886.

Valentine, S. C., D. Contreras, S. Tan, L. J. Real, S. Chu and H. H. Xu. 2008. Phenotypic and molecular characterization of Acinetobacter baumannii clinical isolates from nosocomical outbreaks in Los Angeles County, California. Journal of Clinical Microbiology. 46: 2499-2507.

Xu, H. H., L. Real, and M. W. Bailey. 2006. An array of Escherichia coli clones over-expressing essential proteins: an new strategy of identifying cellular targets of potent antibacterial compounds. Biochemical and Biophysical Research Communications. 349 (4): 1250-1257.

Forsyth, R. A., R. J. Haselbeck, K. L. Ohlsen, R. T. Yamamoto, H. Xu, J. D. Trawick, D. Wall, L. Wang, V. Brown-Driver, J. M. Froelich, G. C. Kedar, P. King, M. McCarthy, C. Malone, B. Misiner, D. Robbins, Z. Tan, Z, Zhu, G. Carr, D. A. Mosca, C. Zamudio, J. G. Foulkes, and J. W. Zyskind. 2002. A genome-wide strategy for the identification of essential genes in Staphylococcus aureus. Molecular Microbiology. 43:1387-1400.

Xu, H. H. 1998. ATP-TOX system - a review. pp153-159. in P. G. Wells, K. Lee and C. Blaise (eds.) Microscale Aquatic Toxicology - Advances, Techniques and Practice. CRC Lewis Publishers, Boca Raton, Florida.

Xu, H. H. and F. R. Tabita. 1996. Ribulose bisphosphate carboxylase/oxygenase gene expression and diversity in Lake Erie planktonic microorganisms. Applied and Environmental Microbiology. 62: 1913-1921.

Gibson, J. L., Y. Qian, G. C. Paoli, J. M. Dubbs, H. H. Xu, H. V. Modak, K. M. Horken, T. M. Wahlund, G. M. F. Watson and F. R. Tabita. 1996. Molecular control and biochemistry of CO2 fixation in photosynthetic bacteria. in M. E. Lidstrom and F. R. Tabita (eds.) The Proceedings of 8th International C1 Symposium. Kluwer Academic Publishers, The Netherlands.

Xu, H. H., J. Janka, M. Viebahn and R. S. Hanson. 1995. Nucleotide sequence of mxcQ and mxcE genes, required for methanol dehydrogenase synthesis in Methylobacterium organophilum strain XX: a two component regulatory system. Microbiology 141: 2543-2551.

Xu, H. H. and F. R. Tabita. 1994. Positive and negative regulation of sequences upstream of the form II cbb CO2 fixation operon of Rhodobacter sphaeroides. Journal of Bacteriology. 176: 7299-7308.

Xu, H. H., M. Viebahn and R. S. Hanson. 1993. Identification of methanol regulated promoters from Methylobacterium organophilum XX. Journal of General Microbiology. 139: 743-752.


Patents and Patent Applications

Zyskind, J. W., Ohlsen, K.L., Trawick, J.D., Forsyth, R. A., Froelich, J. M., Carr, G. J., Yamamoto, R. T., Xu, H. 2000. Genes identified as required for proliferation in Escherichia coli. US# 6,720,139.

Haselbeck, R., Ohlsen, K. L., Zyskind, J. W., Wall, D., Trawick, J. D., Carr, G. J., Yamamoto, R.T., Xu, H. H. 2001. Genes identified as required for proliferation in bacteria. Publication No. WO 0170955.

Carr, G., Xu, H. H., Foulkes, J. G., Zamudio, C., Haselbeck, R., Ohlsen, K. L., Zyskind, J. W., Wall, D., Trawick, J. D., Yamamoto, R. T., Roemer, T., Jiang, B., Boone, C., Bussey, H. 2001. Methods for identifying the target of a compound which inhibits cellular proliferation. Publication No. WO 02086097.

Wang, L., Zamudio, C., Malone, C., Haselbeck, R., Ohlsen, K. L., Zyskind, J. W., Wall, D., Trawick, J. D., Carr, G. J., Yamamoto, R., Forsyth, R. A., Xu, H. H. 2002. Identification of essential genes in microorganisms.  Publication No. WO 02077183.




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