Our laboratory is dedicated to investigating the structure-function relationship of cyclodextrins in scavenging toxic agents from various complex environments. We achieve this through synthesizing cyclodextrins and assessing their interactions with drugs, pesticides, dyes, and persistent organic pollutants (POPs).
Organic Synthesis
Cyclodextrin Modifications
Monotosylation of the cyclodextrin primary face is used to add sulfide, amine, and ether-linked functional groups to one glucopyranose unit of α, β, or γCDs. The introduction of the new linker breaks CD symmetry and introduces the potential for enhanced interactions. Rational design combined with a systematic study of monofunctionalized derivatives will give us insights to strengthen CD/target complex interactions.