I received my Ph.D. in Microbiology from Ewha Womans University (Seoul, Korea) in 2002, followed by my postdoctoral training in mycology and molecular biology at the Division of Infectious Diseases, Harbor-UCLA Medical Center. I joined the Department of Biological Sciences at Cal State LA in 2008.
My research focuses on the molecular mechanisms of fungal pathogenesis using Candida albicans as a model system. Fungal infections have recently emerged as a consistently growing threat to human health, especially in persons whose immune systems are compromised in some way. As part of normal microbiota on human body, C. albicans become the most leading cause of serious superficial and disseminated infections in immunocompromised populations. Since C. albicans interacts with various host cells during the initiation of infection, this organism has likely acquired the ability to express niche-specific genes during the initiation of superficial or disseminated infection. I have dedicated my research efforts to identify key virulence factors governing C. albicans pathogenesis. Our recent research with my research students has discovered that Casein kinase I in C. albicans plays a crucial role in governing morphology transition, cellular integrity, stress response, and host cell interaction. As part of the signaling cascade pathway detecting the environmental changes where C. albicans is placed, Casein Kinase I is believed to interact with various cellular components including transcription factors, which governs that gene expression of the responsive elements. My current research approaches are to elucidate the molecular mechanisms by which Casein Kinae I in C. albicans governs morphology transition and cellular integrity.
- MICR3100 General Microbiology
- MICR440 Fungal Pathogenesis
- BIOL4160 Molecular Genetics
- BIOL4170 Gene Manipulation
- Ph.D. Microbiology (emphasis in mycology and molecular biology) 2002 - Ewha Womans University, Korea
- M.S. Microbiology 1998 - Ewha Womans University, Seoul Korea
- B.S. Biology ( Minor: science Education) 1996 - Ewha Womans University, Korea
S.-I. Jung, N. Rodriguez, S. Zhu, J. Irrizary, J. Garcia Castillo, S.G. Filler, E. Eivers, E. Porter, and H. Park. 2016. Yeast Casein Kinase 2 plays an important role in governing morphology, stress response, and cell integrity of Candida albicans. Scientific Report (Sumbitted)
- Park H, Solis N, Louie J, Spellberg B, Rodriguez N, and Filler SG. Different tumor necrosis factor α antagonists have different effects on host susceptibility to disseminated and oropharyngeal candidiasis in mice. 2014 Virulence 5:5, 1-5.
- Phan QT, Eng DK, Mostowy S, Park H, Cossart P, and Filler SG. Role of Endothelial Cell Septin 7 in the Endocytosis of Candida albicans. 2013 M. Bio 4(6) 542-13.
- Park H, Liu Y, Solis N, Spotkov J, Hamaker J, Blankenship JR, Yeaman MR, Mitchell AP, Liu H and Filler SG. Transcriptional responses of Candida albicans to epithelial and endothelial cells. 2009 Eukaryotic Cell 8:1498-1510
- Gank KD, Yeaman MR, Kojima S, Yount NY, Park H, Edwards, Jr. JE, Filler SG, and Fu Y. SSD1 is Integral to Host Defense Peptide Resistance in Candida albicans. 2008 Eukaryot Cell 7(8):1318-1327
- Barker KS, Park H, Phan QT, Xu L, Homayouni R, Rogers PD, Filler SG. Transcriptome Profile of the Vascular Endothelial Cell Response to Candida albicans. 2008 J. Infect Dis. 198:193–202
- Goyard S, Knechtle P, Chauvel M, Mallet A, Prévost MC, Proux C, Coppée JY, Schwartz P, Dromer F, Park H, Filler SG, Janbon G, d'Enfert C. The Yak1 Kinase is Involved in the Initiation and Maintenance of Hyphal Growth in Candida albicans. 2008 Mol Biol Cell.19(5), 2251-2266
- Thewes S, Kretschmar M, Park H, Schaller M, Filler SG, Hube B. In vivo and ex vivo comparative transcriptional profiling of invasive and non-invasive Candida albicans isolates identifies genes associated with tissue invasion. 2007 Mol Microbiol. 2007 Mar;63(6):1606-28.
- Martinez-Lopez R, Park H, Myers CL, Gil C, Filler SG. Candida albicans Ecm33p is important for normal cell wall architecture and interactions with host cells.2006 Eukaryot Cell. 2006 Jan;5(1):140-7
- Park H, Myers CL, Sheppard DC, Phan QT, Sanchez AA, E Edwards J, Filler SG. Role of the fungal Ras-protein kinase A pathway in governing epithelial cell interactions during oropharyngeal candidiasis. 2005 Cell Microbiol. 2005 Apr;7(4):499-510.
- Choi S, Park N, Park H, Park M, Woo J, Choi W Interacting domain between yeast chitin synthase 3 and chitin synthase 4 is involved in angiogenesis of chitin ring, but not for cell wall chitin. 2004 J Microbiol Biotechnol 13:263-268
- Park H, Choi S, Park N, Kim C, Kim S, Choi W Identification of a domain in yeast chitin synthase 3 interacting with chitin synthase 4 by two hybrid analysis. J Microbiol Biotechnol 2002 12:943-949
Kim M, Park H, C Kim, Park H, Choi W Inhibition of chitin synthases by nikkomycin is dependent on media composition in Candida albicans. 2002 Yeast 19:341-349.
- Min J, Lee Y, Kim Y, Park H, Han S, Jhon G-J, Choi W Lysophosphatidylcholine derived from deer antler extract suppresses hyphal transition in Candida albicans through MAP kinase activity. Biochim Biophysica Acta 2001 1531:77-89.
Park H, Jhon G-J, Choi W Hyphal growth inhibition by deer antler extract mimics the effect of chitin synthase deletion in Candida albicans. 1998 J Microbiol Biotechnol 8:422-425
Park H, John G-J, Choi W Deer antler extract selectively suppresses hyphal growth in dimorphic fungus, Candida albicans. 1998 J Microbiol Biotechnol 8:291-29