Hyunsook Park

H Park info

 

BACKGROUND

Dr.Park received her Ph.D. Microbiology from Ewha Womans University (Seoul, Korea)  in 2002, followed by postdoctoral training in mycology and molecular biology at the Division of Infectious Diseases, Harbor-UCLA Medical Center.  Dr. Park joined the Department of Biological Sciences at Cal State LA in 2008.

TEACHING INTERESTS

Dr. Park currently teaches lecture courses in General Microbiology, Molecular Genetics and Fungal pathogenesis. She also teaches lab courses in Genearal Microbiology, Clinical Microbiology,  and Pathogenic Bacteria. In addition, she provides research training to the students in the Department of Biological Sciences.

RESEARCH

My research focuses on the molecular mechanisms of fungal pathogenesis using Candida albicans as a model system. Fungal infections have recently emerged as a consistently growing threat to human health, especially in persons whose immune systems are compromised in some way. As a pleomorphic fungus, Candida albicans changes morphologies from yeast, to pseudohyphae, and to hyphae in response to various environmental signals. The regulatory networks governing this process are, however, extremely complex and remain to be completely elucidated.  I have dedicated my research efforts to identify key virulence factors governing C. albicans pathogenesis. Our recent research with my research students has discovered that Casein kinase I in C. albicans plays a crucial role in governing morphology transition, cellular integrity, stress response, and host cell interaction by gene deletion analysis. As part of the signaling cascade pathway detecting the environmental changes where C. albicans is placed, Casein Kinase I is believed to interact with various cellular components including transcription factors, which governs that gene expression of the responsive elements. My current research approaches are to elucidate the molecular mechanisms by which Casein Kinae I in C. albicans governs morphology transition and cellular integrity.

 

Recent Publications

  1. S.-I. Jung, N. Rodriguez, J. Irrizary, K. Liboro, M. Macias, T. Bogarin, E. Porter, E. Eivers, S.G. Filler,and H. Park. Yeast casein kinase 2 plays an important role in governing morphology, stress response, and cell integrity of Candida albicans. PLOS ONE, 2017.
  2. Park H, Solis N, Louie J, Spellberg B, Rodriguez N, and Filler SG. Different tumor necrosis factor α antagonists have different effects on host susceptibility to disseminated and oropharyngeal candidiasis in mice. Virulence 5:5, 1-5, 2014.
  3. Phan QT, Eng DK, Mostowy S, Park H, Cossart P, and Filler SG. Role of Endothelial Cell Septin 7 in the Endocytosis of Candida albicans. M. Bio 4(6) 542-13, 2013.
  4. Park H, Liu Y, Solis N, Spotkov J, Hamaker J, Blankenship JR, Yeaman MR, Mitchell AP, Liu H and Filler SG. Transcriptional responses of Candida albicans to epithelial and endothelial cells. Eukaryotic Cell 8:1498-1510, 2009.
  5. Gank KD, Yeaman MR, Kojima S, Yount NY, Park H, Edwards, Jr. JE, Filler SG, and Fu Y. SSD1 is Integral to Host Defense Peptide Resistance in Candida albicans. Eukaryot Cell 7(8):1318-1327, 2008.
  6. Barker KS, Park H, Phan QT, Xu L, Homayouni R, Rogers PD, Filler SG. Transcriptome Profile of the Vascular Endothelial Cell Response to Candida albicans. J. Infect Dis. 198:193–202 (Equally contributed first author), 2008.
  7. Goyard S, Knechtle P, Chauvel M, Mallet A, Prévost MC, Proux C, Coppée JY, Schwartz P, Dromer F, Park H, Filler SG, Janbon G, d'Enfert C.  The Yak1 Kinase is Involved in the Initiation and Maintenance of Hyphal Growth in Candida albicans. Mol Biol Cell.19(5), 2251-2266, 2008.
  8. Thewes S, Kretschmar M, Park H, Schaller M, Filler SG, Hube B.  In vivo and ex vivo comparative transcriptional profiling of invasive and non-invasive Candida albicans isolates identifies genes associated with tissue invasion.    Mol Microbiol. 2007 Mar;63(6):1606-28, 2007.
  9. Martinez-Lopez R, Park H, Myers CL, Gil C, Filler SG. Candida albicans Ecm33p is important for normal cell wall architecture and interactions with host cells. Eukaryot Cell. 2006 Jan;5(1):140-7, 2006.
  10. Park H, Myers CL, Sheppard DC, Phan QT, Sanchez AA, E Edwards J, Filler SG. Role of the fungal Ras-protein kinase A pathway in governing epithelial cell interactions during oropharyngeal candidiasis. Cell Microbiol. 2005 Apr;7(4):499-510, 2005.
  11. Choi S, Park N, Park H, Park M, Woo J, Choi W  Interacting domain between yeast chitin synthase 3 and chitin synthase 4 is involved in angiogenesis of chitin ring, but not for cell wall chitin.  J Microbiol Biotechnol 13:263-268, 2003.
  12. Park H, Choi S, Park N, Kim C, Kim S, Choi W  Identification of a domain in yeast chitin synthase 3 interacting with chitin synthase 4 by two hybrid analysis.  J Microbiol Biotechnol 12:943-949, 2002.
  13. Kim M, Park H, C Kim, Park H, Choi W  Inhibition of chitin synthases by nikkomycin is dependent on media composition in Candida albicans.  Yeast 19:341-349, 2002.
  14. Min J, Lee Y, Kim Y, Park H, Han S, Jhon G-J, Choi W  Lysophosphatidylcholine derived from deer antler extract suppresses hyphal transition in Candida albicans through MAP kinase activity.  Biochim Biophysica Acta 1531:77-89, 2001.
  15. Park H, Jhon G-J, Choi W  Hyphal growth inhibition by deer antler extract mimics the effect of chitin synthase deletion in Candida albicans.  J Microbiol Biotechnol 8:422-425, 1998.
  16. Park H, John G-J, Choi W  1998 Deer antler extract selectively suppresses hyphal growth in dimorphic fungus, Candida albicans.  J Microbiol Biotechnol 8:291-294, 1998. 

EDUCATIONAL BACKGROUND 

  • Ph.D. Microbiology (emphasis in mycology and molecular biology) 2002 -  Ewha Womans University,  Korea
  • M.S. Microbiology 1998 - Ewha Womans University, Seoul Korea
  • B.S. Biology ( Minor: science Education) 1996 - Ewha Womans University,  Korea