Spinal Plasticity Laboratory
Objectives
We are using a rodent model of spinal cord injury to study how hind limb treadmill training improves locomotor recovery. Our current projects are studying:
| Robotic locomotor training |
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Drug treatments for paralysis | Biochemistry of spinal neurons | |
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We are using drug treatments, i.e. quipazine, in combination with robotic-assisted locomotor training to improve stepping in spinal cord injured rats. |
We are investigating how lumbar spinal neurons change in response to robotic-assisted locomotor training. In particular, we are studying the synthesis of a neurotrohpin, brain-derived neuorotrophic factor (BDNF), by motor neurons in the spinal cord. |
The findings of these studies will have important implications for current locomotor training therapies for people with spinal cord injuries. For example, the rodent robotic device provides a test bed for developing robotic trainers for human body weight supported treadmill training.
Contact Info/Location
To become involved in SPL research, call (323) 343-6054.
We
use a robotic locomotor system to train the hind limbs to step on a
treadmill. We are learning how to best apply forces on the rat hind limbs to
teach the injured spinal cord to step. 