Department of Biological Sciences
Philip S. LaPolt
Assistant Vice President for AcademicAffairs - Academic Personnel
Professor,
Department of Biological Sciences
Office: Administration Building Room 707
Phone: (323) 343-3810
email address: plapolt@exchange.calstatela.edu
Dr. LaPolt received his Ph.D. in Anatomy at the University of
California, Los Angeles in 1988, followed by postdoctoral training in
Reproductive Endocrinology/Cellular
& Molecular Biology at U.C. San Diego and Stanford University.
Dr. LaPolt has taught courses in Human Anatomy &
Physiology
and Endocrinology. In addition, he provides research training to
undergraduate
and graduate students in the Dept. of Biological Sciences.
Dr. LaPolt's research program focuses on the regulation of gene expression in the reproductive system, with emphasis on the signaling mechanisms regulating ovarian granulosa cell maturation and the effects of aging on the neuroendocrine mechanisms regulating gonadotropin synthesis and release. Listed below are some of his more recent research publications.
| Date | Recent Publications (since 1995 only) |
| 2005 | Shi F, Perez E, Wang T, Peitz B, LaPolt PS. Stage- and cell-specific expression of soluble guanylyl cyclase alpha and beta subunits, cGMP-dependent protein kinase I alpha and beta, and cyclic nucleotide-gated channel subunit 1 in the rat testis. J Androl. 26:258-63 (erratum J Androl 26:804) |
| 2004 |
Tafoya MA, Chen JY, Stewart RL Jr, LaPolt PS. Activation of soluble guanylyl cyclase inhibits estradiol production and cyclic AMP accumulation from cultured rat granulosa cells. Fertil Steril 82 Suppl 3:1154-9 |
| 2004 |
Tsai HW, LaPolt PS, Olcott AP, Lu JK. Temporal changes occur in the neuroendocrine control of gonadotropin secretion in aging female rats: role of progesterone. Biol Reprod 71:845-52 |
| 2004 |
Shi F, Stewart RL Jr., Perez E, Chen
JY-H,
LaPolt PS. Cell-specific expression and regulation of soluble
guanylyl cyclase alpha and beta subunits in the rat ovary. Biol
Reprod
70:1552-61. |
| 2003 | Shi F, LaPolt PS. Relationship between FOX01 protein levels and follicular development, atresia, and luteinization in the rat ovary. J Endocrinol 179:195-203 |
| 2003 | Sinchak K, Mills RH, Tao L, LaPolt P, Lu JKH, Micevych P. Estrogen induces de novo progesterone synthesis in astrocytes. Developmental Neuroscience 25:343-348. |
| 2003 | Micevych P, Sinchak K, Mills RH, Tao L, LaPolt P, Lu JKH. Estrogen-induced hypothalamic progesterone synthesis regulates luteinizing hormone release. Neuroendocrinology 78:29-35. |
| 2003 | Chen Y-HJ, Tafoya M, Ngo A, LaPolt PS. Effects of nitric oxide and cGMP on inhibin-A and inhibin subunit mRNA levels from cultured rat granulosa cells. Fertil Steril 79(Suppl 1):687-93 |
| 2003 | LaPolt PS, Leung K, Ishimaru R, Tafoya MA, Chen JY-H Roles of Cyclic GMP in Modulating Ovarian Functions. Reprod Biomed Online 6:15-23. |
| 2001 | Yi SE, LaPolt PS, Yoon BS, Chen JY-H, Lu JKH, Lyons KM The type I BMP receptor BmprIB is essential for female reproductive function. Proc Natl Acad Sci (USA) 98:7994-7999. |
| 2001 | LaPolt PS, Lu JKH. Effects of aging on luteinizing hormone secretion, ovulation, and ovarian tissue-type plasminogen activator expression. Experimental Biol Med 226:127-132. |
| 2001 | LaPolt PS, Lu JKH. Factors influencing the onset of female reproductive senscence. In, Functional Neurobiology of Aging, PR Hof & CR Mobbs (eds), Academic Press, San Diego, CA, pp 761-768. |
| 2001 | Anzalone CR, Hong LS, Lu JK, LaPolt PS. Influences of age and ovarian follicular reserve on estrous cycle patterns, ovulation, and hormone secretion in the Long-Evans rat. Biol Reprod. 64:1056-62. |
| 2001 | Ishimaru RS, Leung K, Hong L, LaPolt PS. Inhibitory effects of nitric oxide on estrogen production and cAMP levels in rat granulosa cell cultures. J Endocrinol. 168:249-55. |
| 2000 | Chern B-Y, Chen Y-H, Hong L-S, LaPolt PS. Ovarian steroidogenic responsiveness to exogenous gonadotropin stimulation in young and middle-aged female rats. Proc Soc Exp Biol Med 224:285-291. |
| 1999 | Chun SY, McGee EA, Hsu SY, Minami S, LaPolt PS, Yao HHC, Bahr JM, Gougeon A, Schomberg DW, Hsueh AJW Restricted expression of WT1 messenger ribonucleic acid in immature ovarian follicles: uniformity in mammalian and avian species and maintenance during reproductive senescence. Biol Reprod 60:365-373. |
| 1998 | LaPolt PS, Matt DW, Lu JKH The effects of progesterone implants on age-related declines in regular estrous cyclicity and the ovarian follicular reserve in female rats. Biol Reprod 59:197-201. |
| 1998 | Anzalone CR, Lu JKH, LaPolt PS Influences of age and reproductive status on ovarian ovulatory responsiveness to gonadotropin stimulation. Proc Exp Biol Med 217:455-460. |
| 1997 | McGee E, Perlas E, LaPolt PS, Tsafriri A, Hsueh AJW. FSH enhances the development of preantral follicles in juvenile rats. Biol Reprod 57:990-998. |
| 1995 | LaPolt PS, Hong L.S. Inhibitory effects of superoxide dismutase and cyclic guanosine 3', 5'-monophosphate on estrogen production in cultured rat granulosa cells. Endocrinology 136:5533-5539. |
| 1995 | Heiner JS, Greendale GA, Kawakami AK, LaPolt PS, Fisher M, Young D, Judd HL. Comparison of a gonadotropin-releasing hormone agonist and a low dose oral contraceptive given alone or together in the treatment of hirsutism. J Clin Endocrinol Metab 80:3412-8. |
| 1995 | Thompson KA, LaPolt PS, River J, Henderson G, Dahl KD, Meldrum DR. Gonadotropin requirements of the developing follicle. Fertil Steril 63:273-6 |
EDUCATIONAL BACKGROUND
Ph.D. Anatomy 1988
University of California, Los Angeles Los Angeles, CA
University of California, Los Angeles Los Angeles, CA