Division of Academic Affairs
Department of Biological
Philip S. LaPolt
Assistant Vice President for
AcademicAffairs - Academic Personnel
Department of Biological Sciences
Office: Administration Building Room 707
Phone: (323) 343-3810
email address: firstname.lastname@example.org
Dr. LaPolt received his Ph.D. in Anatomy at the University of
California, Los Angeles in 1988, followed by postdoctoral training in
& Molecular Biology at U.C. San Diego and Stanford University.
Dr. LaPolt has taught courses in Human Anatomy &
and Endocrinology. In addition, he provides research training to
and graduate students in the Dept. of Biological Sciences.
Dr. LaPolt's research program focuses on the regulation of
expression in the reproductive system, with emphasis on the signaling
regulating ovarian granulosa cell maturation and the effects of aging
the neuroendocrine mechanisms regulating gonadotropin synthesis and
Listed below are some of his more recent research publications.
Recent Publications (since 1995 only)
||Shi F, Perez E, Wang T, Peitz B, LaPolt PS. Stage- and
cell-specific expression of soluble guanylyl cyclase alpha and beta
subunits, cGMP-dependent protein kinase I alpha and beta, and cyclic
nucleotide-gated channel subunit 1 in the rat testis. J Androl.
26:258-63 (erratum J Androl 26:804)
|Tafoya MA, Chen JY,
Stewart RL Jr, LaPolt PS. Activation of soluble guanylyl cyclase
estradiol production and cyclic AMP accumulation from cultured rat
granulosa cells. Fertil Steril 82 Suppl 3:1154-9
LaPolt PS, Olcott AP, Lu JK. Temporal
changes occur in the neuroendocrine control of gonadotropin secretion
in aging female rats: role of progesterone. Biol Reprod 71:845-52
| Shi F, Stewart RL Jr., Perez E, Chen
LaPolt PS. Cell-specific expression and regulation of soluble
guanylyl cyclase alpha and beta subunits in the rat ovary. Biol
||Shi F, LaPolt PS. Relationship between FOX01 protein
levels and follicular development, atresia, and luteinization in the
rat ovary. J Endocrinol
||Sinchak K, Mills RH, Tao L, LaPolt P, Lu JKH, Micevych
P. Estrogen induces de novo progesterone synthesis in
astrocytes. Developmental Neuroscience 25:343-348.
||Micevych P, Sinchak K, Mills RH, Tao L, LaPolt P, Lu
JKH. Estrogen-induced hypothalamic progesterone synthesis
regulates luteinizing hormone release. Neuroendocrinology
||Chen Y-HJ, Tafoya M, Ngo A, LaPolt PS. Effects of
nitric oxide and cGMP on inhibin-A and inhibin subunit mRNA levels from
cultured rat granulosa
cells. Fertil Steril 79(Suppl 1):687-93
||LaPolt PS, Leung K, Ishimaru R, Tafoya MA, Chen JY-H
Roles of Cyclic GMP in Modulating Ovarian Functions. Reprod
Biomed Online 6:15-23.
||Yi SE, LaPolt PS, Yoon BS, Chen JY-H, Lu JKH, Lyons KM
The type I BMP receptor BmprIB is essential for female reproductive
function. Proc Natl Acad Sci (USA) 98:7994-7999.
||LaPolt PS, Lu JKH. Effects of aging on
luteinizing hormone secretion, ovulation, and ovarian tissue-type
plasminogen activator expression. Experimental Biol Med
||LaPolt PS, Lu JKH. Factors influencing the onset
of female reproductive senscence. In, Functional Neurobiology of
Aging, PR Hof & CR Mobbs
(eds), Academic Press, San Diego, CA, pp 761-768.
||Anzalone CR, Hong LS, Lu JK, LaPolt PS. Influences of
age and ovarian follicular reserve on estrous cycle patterns,
ovulation, and hormone secretion in the Long-Evans rat. Biol Reprod.
||Ishimaru RS, Leung K, Hong L, LaPolt PS.
Inhibitory effects of nitric oxide on estrogen production and cAMP
levels in rat granulosa cell cultures. J Endocrinol. 168:249-55.
||Chern B-Y, Chen Y-H, Hong L-S, LaPolt PS. Ovarian
steroidogenic responsiveness to exogenous gonadotropin stimulation in
young and middle-aged female rats. Proc Soc Exp Biol Med
||Chun SY, McGee EA, Hsu SY, Minami S, LaPolt PS, Yao
HHC, Bahr JM, Gougeon A, Schomberg DW, Hsueh AJW Restricted expression
of WT1 messenger ribonucleic acid in immature ovarian follicles:
uniformity in mammalian and avian species and maintenance during
reproductive senescence. Biol Reprod 60:365-373.
||LaPolt PS, Matt DW, Lu JKH The effects of progesterone
implants on age-related
declines in regular estrous cyclicity and the ovarian follicular
in female rats. Biol Reprod 59:197-201.
||Anzalone CR, Lu JKH, LaPolt PS Influences of age and
reproductive status on ovarian ovulatory responsiveness to gonadotropin
stimulation. Proc Exp Biol Med 217:455-460.
||McGee E, Perlas E, LaPolt PS, Tsafriri A, Hsueh AJW.
FSH enhances the development of preantral follicles in juvenile rats.
Biol Reprod 57:990-998.
||LaPolt PS, Hong L.S. Inhibitory effects of superoxide
dismutase and cyclic guanosine 3', 5'-monophosphate on estrogen
production in cultured rat
granulosa cells. Endocrinology 136:5533-5539.
||Heiner JS, Greendale GA, Kawakami AK, LaPolt PS, Fisher
M, Young D, Judd HL. Comparison of a gonadotropin-releasing
hormone agonist and a low dose oral contraceptive given alone or
together in the treatment of
hirsutism. J Clin Endocrinol Metab 80:3412-8.
||Thompson KA, LaPolt PS, River J, Henderson G, Dahl KD,
Meldrum DR. Gonadotropin
requirements of the developing follicle. Fertil Steril 63:273-6
Ph.D. Anatomy 1988
University of California, Los Angeles
Los Angeles, CA