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| Workshop A-Find the complete amino acid sequence of human p53 and perform a secondary structure prediction with PSIPRED or another secondary structure prediction algorithm. Have the results emailed to you or displayed on your computer. Explain the results to the instructor. |
| Workshop B-Check to see if the BLIMPs program in the BLOCK searcher can predict the function of PTEN (protein sequence accession number NP_000305). PTEN is an abbreviation for phosphatase and tensin homolog Obtain sequence from protein database at NCBI. Convert to FASTA format. Paste sequence into window in BLOCK Searcher (http://blocks.fhcrc.org/blocks/blocks_search.html). Determine the major function based on thee BLOCK Searcher output. Determine the actual function of PTEN by performing a text search for PTEN in the OMIM database. Did the BLOCK searcher correctly predict the function of PTEN? |
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