Alicia Izquierdo (Edler)
Associate Professor
College of Natural and
Social Sciences
Department of Psychology
Office: La Kretz Hall 254
Office Phone: 323-343-2283
Lab: La Kretz Hall 334
Lab Phone: 323-343-5033
E-mail:
aizquie@calstatela.edu
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INTRODUCTION
One of my main professional goals is to encourage
women and ethnic minorities to pursue research careers
in behavioral neuroscience. To this end, I try to expose
my students to the many career options within Psychology
and also try to infuse a passion for the puzzle-solving
nature of research in my teaching and mentoring.
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TEACHING INTERESTS
Because of my research background in cognitive and
behavioral neuroscience, I particularly enjoy teaching
courses on Brain and Behavior, Emotion and Motivation, as
well as graduate seminars in Neuropsychopharmacology and
Advanced Experimental Design. In order to better involve
students in research I try to stimulate critical
thinking and encourage the development of unique
research questions in their area of interest.
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RESEARCH
Our lab's main research interests include: Uncovering the neural
mechanisms important for flexible cognition and
behavior, exploring the factors contributing to
reward-related decision-making, and studying the
neuropharmacology of [and effects of psychostimulants
on] executive function. At best, addressing these
research questions could contribute to a better
understanding (and treatment) of addiction and relapse, and diseases such as OCD,
PTSD, and Impulse Control Disorder.
CURRENT FUNDING
NIH NIGMS 1SC2 MH087974-01 $433, 500 "Methamphetamine
effect on cognitive flexibility" 2009-2012
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REPRESENTATIVE PUBLICATIONS
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Title |
Date |
| Kosheleff AR, Rodriguez D, O’Dell SJ, Marshall JF, Izquierdo A. Comparison of single-dose and escalating methamphetamine administration on reversal learning in rats. Psychopharmacology |
In press |
| Izquierdo A, Carlos K, Ostrander S, Rodriguez D, McCall-Craddolph, Yagnik G, Zhou F. Impaired reward learning and intact motivation after serotonin depletion in rats. Behavioural Brain Research DOI 10.1016/j.bbr.2012.05.032. |
2012 |
| Izquierdo A and Jentsch JD. Reversal learning as a measure of impulsive and compulsive behavior in addictions. In Robbins TW (Ed.) Impulsivity and Compulsivity. Psychopharmacology 219 (2): 607-20. |
2012 |
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Barkus C, Feyder M,
Graybeal C, Wright T, Wiedholz L, Izquierdo A,
Kiselycznyk C, Schmitt W, Sanderson DJ, Rawlins
JN, Saksida LM, Bussey TJ, Sprengel R, Bannerman
D, Holmes A. Do GluA1 knockout mice exhibit
behavioral abnormalities relevant to the
negative or cognitive symptoms of schizophrenia
and schizoaffective disorder?
Neuropharmacology
DOI:10.1016/j.neuropharm.2011.06.005. |
2011 |
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Kosheleff AR, Grimes
M, O'Dell SJ, Marshall JF, Izquierdo A. Work
aversion and associated changes in dopamine and
serotonin transporter after methamphetamine
exposure in rats. Psychopharmacology
Online First DOI: 10.1007/s00213-011-2367-4. |
2011 |
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Ostrander S, Cazares
VA, Kim C, Cheung S, Gonzalez I and Izquierdo A.
Orbitofrontal cortex and basolateral amygdala
lesions result in suboptimal and dissociable
reward choices on cue-guided effort in rats. In Baxter, MG (Ed.)
Translating
models in Prefrontal Cortex Function.
Behavioral Neuroscience 125(3): 350-359. APA Journals. |
2011 |
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Izquierdo A and
Belcher AM. Rodent Models of Adaptive
Decision Making. In Kobeissy, FH
(Ed.) Psychiatric Disorders: Methods and
Protocols. Humana Press: New York. |
2011 |
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Brigman JL, Mathur
P, Harvey-White J, Izquierdo A, Saksida LM,
Bussey TJ, Fox S, Deneris E, Murphy DL, Holmes
A. Pharmacological or genetic inactivation of
the serotonin transporter improves reversal
learning in mice. Cerebral Cortex 20(8): 1955-1963. |
2010 |
|
Izquierdo A and
Murray EA. Functional interaction of
medial mediodorsal thalamic nucleus but not
nucleus accumbens with amygdala and orbital
prefrontal cortex is essential for adaptive
response selection after reinforcer devaluation.
The Journal of Neuroscience 30: 661-669. |
2010 |
|
Izquierdo A, Belcher
AM, Scott L, Cazares VA, Chen J, O'Dell SJ,
Malvaez M, Wu T, and Marshall JF.
Reversal-specific learning impairments after a
binge regimen of methamphetamine in rats:
Possible involvement of striatal dopamine.
Neuropsychopharmacology 35: 505-514. |
2010 |
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Chudasama Y,
Izquierdo A, Murray EA. Distinct
contributions of the amygdala and hippocampus to
fear expression. European Journal of
Neuroscience 30: 2327-2337. |
2009 |
|
Murray EA, Izquierdo
A, and Malkova L. Amygdala function in
positive reinforcement: Contributions from
studies of nonhuman primates. In: Whalen PJ, and
Phelps EA (Eds) The Human Amygdala, Guilford,
New York.
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2009 |
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Murray EA, Izquierdo A. Orbitofrontal cortex and
amygdala contributions to affect and action in
primates. Ann NY Acad Sci
1121:273-296. |
2007 |
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Izquierdo A, Newman TK, Higley JD, Murray EA. Genetic modulation of cognitive
flexibility and socioemotional behavior in
rhesus monkeys. PNAS USA 104:
14128-14133. |
2007 |
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Wellman CL, Izquierdo A, Garrett JE, Martin KP,
Carroll J, Millstein R, Lesch KP, Murphy DL, and
Holmes A. Impaired stress-coping and fear
extinction and abnormal corticolimbic morphology
in serotonin transporter knock-out mice. The
Journal of Neuroscience 27: 684-691.
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2007 |
|
Izquierdo A and Murray EA. Selective
bilateral amygdala lesions in rhesus monkeys
fail to disrupt object reversal learning. The
Journal of Neuroscience 27: 1054-1062. |
2007 |
|
Izquierdo A, Wellman CL, Holmes A. Stress
causes rapid dendritic retraction in infralimbic
cortex and impairs fear extinction in mice.
The Journal of Neuroscience 26:
5733-5738. |
2006 |
|
Izquierdo A, Wiedholz LM, Millstein RA, Yang RJ,
Bussey TJ, Saksida LM, and Holmes A.
Genetic and dopaminergic modulation of reversal
learning in a touchscreen-based operant
procedure for mice. Behavioural Brain
Research 171: 181-188. |
2006 |
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Izquierdo A
and Murray EA. Opposing effects of amygdala and orbital
prefrontal cortex lesions on the extinction of
instrumental responding in macaque monkeys.
European Journal of Neuroscience 22:
2341-2346. |
2005 |
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Izquierdo A, Suda
RK, and Murray EA. Comparison of the
effects of bilateral orbital prefrontal cortex
lesions and amygdala lesions on emotional
responses in rhesus monkeys. The Journal of
Neuroscience 25: 8534-8542. |
2005 |
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Izquierdo A, Suda
RK, and Murray EA. Bilateral orbital
prefrontal cortex lesions in rhesus monkeys
disrupt choices guided by both reward value and
reward contingency. The Journal of
Neuroscience 24: 7540 – 7548. |
2004 |
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Izquierdo A and
Murray EA. Combined unilateral lesions of
the amygdala and orbital prefrontal cortex
impair affective processing in rhesus monkeys.
Journal of Neurophysiology. 91:
2023-2039. |
2004 |
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Baxter MG, Parker A,
Lindner CCC, Izquierdo AD, Murray EA.
Control of response selection by reinforcer
value requires interaction of amygdala and
orbital prefrontal cortex. The Journal of
Neuroscience. 20(11): 4311-4319. |
2000 |
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EDUCATIONAL BACKGROUND
Ph.D. Cognitive Neuroscience 2003
- The George Washington University
in partnership with
- (Graduate Partnership Program) at The National
Institutes of Health
Washington D.C. and Bethesda, MD
B.S. Biology and Psychology 1996
- Emory University
Atlanta, GA
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