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PREM SEED Grant Research Project

Probing peptide side chain interactions using natural and unnatural peptides


We are investigating some of the noncovalent forces found in protein structures, such as the cation-pi interaction.  Results from these fundamental studies will guide the development of materials with useful properties.  Our approach is to perform “Chemical mutagenesis” on synthetic helical peptides followed by structural studies using circular dichroism and NMR spectroscopy.  These studies will ultimately result in a better understanding of these noncovalent forces, with applications in materials, protein, and pharmaceutical design.