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Biomedical Sciences
Seminar Series
Winter 2007 Poster Presentation
January 26, 2007 at 1 pm
Physical
Sciences Lobby
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Victor Galvan, Renee Williams, Lucinda Robledo, Marysol Navarro, Grace Masangkay, Carlos Hernandez, Gilson Sanchez
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"Complexation of Aβ species with Fe3+"
Renee T. Williams, Dianlu Jiang, Feimeng Zhou*
Department of Chemistry and Biochemistry
California State University, Los Angeles
In collaboration with
Lijie Men and Wang Yishen*
Department of Chemistry
University of California, Riverside
Alzheimer’s disease (AD) is a progressive, neurodegenerative disorder characterized by the deposition of amyloid plaque. The plaque is primarily composed of insoluble beta-amyloid (Aβ) protein fibrils and metals at elevated concentrations. In a human brain, the neurotoxicity of Aβ plaque has been suggested to originate from a Fenton-like reaction wherein the peptide-metal complex(es) is(are) involved in the generation of reactive oxygen species. To date, the majority of studies have focused on Aβ-copper and Aβ-zinc interactions, whereas Aβ-iron complexes have not been extensively investigated. As such, the objective of this research is to 1) show that an Aβ-iron complex is formed, 2) determine if the complex is redox-active, and 3) establish a binding constant for the complex. We will correlate our results obtained in vitro to in vivo observations and attempt to provide insight to the understanding of the Aβ aggregation process and its possible link with oxidative stress.
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