Poster Abstract

Fall 2011 Biomedical Seminar Series

Drosophila oogenesis: a new system for understanding prostaglandin signaling

Dr. Tina Tootle
Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine

Prostaglandins (PGs) are lipid signals produced by cyclooxygenase (COX) enzymes, the targets of non-steroid anti-inflammatory drugs, and mediate diverse biological processes from inflammation and pain to reproduction and cancer progression(1). While PG signaling has been widely studied, the downstream, molecular mechanisms of PG action remain largely unknown. To begin to address this gap in knowledge we need an in vivo system that can be manipulated at both the genetic and pharmacologic levels to probe PG signaling. Drosophila oogenesis or follicle development provides such a system. We have found that Pxt is the Drosophila COX enzyme and is required for many aspects of follicle development(2,3), including the dynamic remodeling of the actin cytoskeleton during a process called nurse cell dumping. 1. Funk CD. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science. 2001;294(5548):1871-5. 2. Tootle TL, Williams D, Hubb A, Frederick R, Spradling A. Drosophile eggshell production: identification of new genes and coordination by Pxt. PLoS One. 2011;6(5):e19943. 3. Tootle TL, Spradling AC. Drosophila Pxt: a cyclooxygenase-like facilitator of follicle maturation. Development (Cambridge, England). 2008;135(5):839-47. Lab website: Department website: Graduate program websites: Biosciences Molecular and Cellular Biology Interdisciplinary program in Genetics SROP/McNair Program (minority undergraduate research opportunity):

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