Untitled Page

April 21, 2006

Cavitands, Capsules and Ferris Wheel

Jorge Osuna
California State University, Los Angeles

Abstract:Synthesizing new cavitand structures and studying their conformation and binding properties is
the goal in our lab. Bridging resorcin[4]arene is of importance in producing cavitands and capsules. In
the early 1980’s Dr. Cram studied resorcin[4]arenes that had been bridged with quinoxaline moeties and
possessed the ability to open and close depending on temperature. Our laboratory has used this structure
referred to tetraquinoxaline as a building block for the synthesis of new cavitands and covalently held capsules
with the ability to change conformation depending on environment.