May 27, 2005

Celebrex and Akt: Blocking the Pathway of Cancer Cell Survival
Erika Reynoso
California State University, Los Angeles

The Akt pathway is a signal transduction pathway involved in cellular growth, survival and movement. Akt controls activation of downstream substrates through phosphorylation; its activation has been found to inhibit cancer cell death and to promote formation and growth of cancer cells. Celecoxib, commercially known as Celebrex, is a non-steroidal anti-inflammatory drug that has been found to block this pathway through inhibition of an upstream kinase, resulting in cancer cell cycle arrest and apoptosis. However, celecoxib has drawbacks, including unfavorable pharmacokinetics and weak inhibition of the Akt pathway. Structure-based optimization of celecoxib has led to the formulation of celecoxib derivatives, of which, OSU-03012 has been shown to be a better inhibitor of the Akt pathway in prostate cancer cell lines. Using timed dose-response experiments with various cancer cell lines, our group has sought to characterize the bioactivity of OSU-03012 in order to evaluate its potential as a novel cancer chemotherapeutic.


Preparation of Building Blocks for Tetraamino-Adamantane Dendrimers

Gina Ramirez
California State University, Los Angeles
MBRS-RISE Undergraduate Student