Poster Abstract

Fall 2011 Biomedical Seminar Series

Friday, November 4

Exploring the connection between physiological and cellular stress in the neuroendocrine control of reproduction

Dr. Mark Lawson
Department of Reproductive Medicine
UC San Diego School of Medicine

Reproduction is an energy-intensive process that requires precise control and integration with other physiological systems. Requirements for a successful reproductive outcome are sufficient energy stores and appropriate timing of fertility. In mammals, control of reproduction is exerted by the gonadotropin-releasing hormone (GnRH)-secreting neurons of the hypothalamus and their target cells, the gonadotropes of the anterior pituitary. Activation of GnRH receptor in gonadotropes stimulates synthesis and secretion of Luteinizing Hormone and Follicle-Stimulating Hormone, which in turn control gonadal function in both males and females. We are investigating the regulation of gene expression by GnRH receptor signaling in the gonadotropes to understand how signals are interpreted and result in differential control of gene expression. Our lab has demonstrated that translational control plays a significant role in gene regulation and may provide the key to understanding the integration of metabolic and neuroendocrine signals in the gonadotropes and consequently, in the control of reproduction. Lab web page: Departmental web page:

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