Poster Abstract

Spring 2012 Biomedical Seminar Series

June 1, 2012

Accelerated C–H Activation Reactions: A Shortcut to Molecular Complexity from Chemical Feedstock

Jin-Quan Yu
Department of Chemistry
The Scripps Research Institute
10550 N. Torrey Pines Road
BCC-372, La Jolla, California, 92037-1000, U.S.A.



Pd(II)-catalyzed enantioselective and position-selective C–H activation reactions are developed using mono-N-protected chiral amino acid ligands. C–H activation intermediates are characterized, offering insights into the origin of the observed stereoselectivity. Most importantly, these chiral ligands are found to accelerate drastically C–H activation reactions, shortening the reaction time from two days to 20 minutes.

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