Winter 2013 Biomedical Seminar Series
January 11, 2013
In vivo catalytic production of NO; How hot dogs can cure cancer
Irvin Coria, MARC U*STAR Fellow
Summer Research Site: University of Arizona
Abstract: Nitric oxide (NO) is an important signaling molecule that has a wide range of biological functions such as vasodilation, neurotransmission, immune response and apoptosis. NO donors have potential to be used as therapeutic agents for the treatment of hypertensive attacks, cancer, and thrombosis. Ruthenium nitrosyl complexes that can act as NO donors are of special interest since they can release NO in vivo upon one-electron reduction and they can also be regenerated in situ by reacting with nitrite (NO2-). Since NO has tumoricidal effects at high concentrations, the catalytic production of NO by a ruthenium-nitrosyl complex can be a useful tool in fighting cancer. In order to better understand this catalytic cycle, a ruthenium nitrosyl complex and its reduced species were synthesized and characterized using cyclic voltammetry, mass spectroscopy, EPR, and NMR. Some fundamental insights of this catalytic cycle will be presented.