February 20, 2004

Multiple Intracellular Messengers for Serotonin 5-HT2 Receptors: Regulation and Function

Dr. Elaine Sanders-Bush
Vanderbilt University

My laboratory investigates the serotonin 5-HT2 subfamily of G protein-coupled receptors. These receptors couple to multiple intracellular signaling pathways; we have devised strategies for exploring these signaling pathways in native systems, allowing us to explore regulation of signaling and potential interplay and cross-talk between receptors and signaling pathways. I will also highlight some of our attempts to link intracellular signaling to animal behavior and psychiatric diseases.

           Chang, M., Zhang, L., Tam, J.P. and Sanders-Bush, E. Dissecting G-protein receptors signaling pathways with membrane permeable blocking peptides: endogenous 5-HT2C receptors in choroid plexus epithelial cells. J. Biol. Chem. 275(10): 7021-7029, 2000.

Price, R.D., Weiner, D.M., Chang, M.S.S., and Sanders-Bush, E. RNA editing of the human serotonin 5-HT2C receptor alters receptor-mediated activation of G13 protein. J. Biol. Chem., 276: 44663-44668, 2001.

Smith, R.L., Barrett, R.J. and Sanders-Bush, E. Characterization of the discriminative stimulus effects of 2,5-dimethoxy-4-iodophenyl)-2-aminopropane in C57BL/6J mice. Pscyhopharmacology, 166: 61-68, 2003.

Sanders-Bush, E, Fentress, H and Hazelwood, L: Serotonin 5-HT2 Receptors: Molecular and genomic diversity.  Molecular Interventions, 3:319-330, 2003.

McGrew, L, Price, RD, Hackler, E, Chang, MSS and Sanders-Bush, E: RNA editing of the human serotonin 5-HT2C receptor disrupts trans-activation of the small G-protein Rho.

Mol. Pharmacol. 65: 252-6, 2004.

WebSite: http://braininstitute.vanderbilt.edu/