PowerPoint Presentation - Differential regulation of Id1, Id2, andTwist in myogenesis and osteogenesis

Significance of Study
oDifferent members of the Id family are overexpressed in different tumor types
oAbnormally highexpression of Twist-1 in cancer cellshas been associated with metastasis
oInvasive breastcancer
oTwist-1 overexpressionprevents normal bone and muscledevelopment
oThe molecular basis ofmechanisms that induce the differentiatedosteoblastic phenotype is poorlyunderstood