PowerPoint Presentation - Differential regulation of Id1, Id2, andTwist in myogenesis and osteogenesis

obHLH transcription factor
oHomodimer or heterodimer with other bHLHproteins (i.e.E proteins)
oRegulates cellmovement and mesoderm development during earlyembryogenesis (i.e. bone andmuscle)
oTwist-1has both positive and negative functions regulating mesenchymal celldifferentiation
oBindsto a conserved E-box sequence (CANNTG) on the promoter region that activates orinhibits transcription of a target gene